Journal of Current Research on Health Sector (JoCReHeS) - ISSN: 2547-9636

Hızlı Erişim


Bu Dergi DOI ve Crosscheck üyesidir


The Effect of Nicotine and Melatonin on Kidney Antioxidant Enzyme Activities in Mice
(The Effect of Nicotine and Melatonin on Kidney Antioxidant Enzyme Activities in Mice )

The Effect of Nicotine and Melatonin on Kidney Antioxidant Enzyme Activities in Mice

 
Yazar : Emine DIRAMAN  , Bahar KESİCİ & Gönül Fatma SOLMAZ  
Türü :
Baskı Yılı : 2018
Sayı : 8 (2)
Sayfa : 103-108
DOI Number: :
Cite : Emine DIRAMAN , Bahar KESİCİ & Gönül Fatma SOLMAZ, (2018). The Effect of Nicotine and Melatonin on Kidney Antioxidant Enzyme Activities in Mice. Journal of Current Researches on Health Sector, 8 (2), p. 103-108. Doi: .
304    218


Özet

In this study, the effects of nicotine and melatonin were researched comparatively on the activities of superoxide dismutase (SOD) and catalase (CAT) as kidney antioxidants enzymes in mice. For this purpose, nicotine and melatonin were given to mice by intraperitonal injection and after the injection at the 2th, 4th, 8th, 12th and 24th hours mice were killed by servical dislocation; and their kidneys were removed. After total enzyme fractions were obtained by applying the kidneys homogenisation, sonification and centrifugation. These fractions were used for the determination of changes in SOD and CAT activities. As a result, it was determined that the CAT activity generally was inhibited but there was a few activation 8th hour by the effect of nicotine. Under the effect of melatonin the CAT activity generally was activated but there was a few inhibition in 2th hour. And it was observed that under the effect of nicotine+melatonin the CAT activity activated 4th and 8th hours but inhibited 2th , 12th and 24th hours. It was determined that the SOD activity was inhibited 2th and 4th hours but activated 8th, 12th and 24th hours by the effect of nicotine. Under the effect of melatonin the SOD activity generally was activated all the hours. And it was observed that under the effect of nicotine+melatonin the SOD activity inhibited 2th, 4th and 24th hours but activited 8th and 12th hours.



Anahtar Kelimeler
Nicotine, Melatonin, Superoxide Dismutase, Catalase, Kidney, Mice

Abstract

In this study, the effects of nicotine and melatonin were researched comparatively on the activities of superoxide dismutase (SOD) and catalase (CAT) as kidney antioxidants enzymes in mice. For this purpose, nicotine and melatonin were given to mice by intraperitonal injection and after the injection at the 2th, 4th, 8th, 12th and 24th hours mice were killed by servical dislocation; and their kidneys were removed. After total enzyme fractions were obtained by applying the kidneys homogenisation, sonification and centrifugation. These fractions were used for the determination of changes in SOD and CAT activities. As a result, it was determined that the CAT activity generally was inhibited but there was a few activation 8th hour by the effect of nicotine. Under the effect of melatonin the CAT activity generally was activated but there was a few inhibition in 2th hour. And it was observed that under the effect of nicotine+melatonin the CAT activity activated 4th and 8th hours but inhibited 2th , 12th and 24th hours. It was determined that the SOD activity was inhibited 2th and 4th hours but activated 8th, 12th and 24th hours by the effect of nicotine. Under the effect of melatonin the SOD activity generally was activated all the hours. And it was observed that under the effect of nicotine+melatonin the SOD activity inhibited 2th, 4th and 24th hours but activited 8th and 12th hours.



Keywords
Nicotine, Melatonin, Superoxide Dismutase, Catalase, Kidney, Mice

Gelişmiş Arama


Duyurular

    Yayın Duyurusu

    Yayına kabul edilen makaleler ilgili sayının yayın tarihi beklenmeden DOI verilmekte ve atıf almasına yönelik "Erken Görünüm" seçeneği ile yayınlanmaktadır. 


    Makale Kabulü Sürmektedir

    Dergimizin 9 (2) sayısı için makale kabulü 30 Kasım 2019 tarihine kadar sürecektir. Makalelerinizi herhangi bir word şablonunda "Online Makale Gönder" linkinden gönderebilirsiniz. Kabul edilen makalelerin tasarım ve mizanpajı dergimizin sekreteryası tarafından yapılmaktadır.



Adres : http://www.jocrehes.com
Telefon : Please contact mail first Faks : Lütfen öncelikle mail ile iletişime geçiniz
Eposta : sra.academic.publishing@gmail.com

Web Yazılım & Programlama Han Yazılım Bilişim Hizmetleri